Disruptors 60 will Return in Fall 2027

Sixty companies. The only list that matters in AI.© 2026 AI Disruptors 60 · A Greenfield Partners program, unveiled at TC Disrupt.
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Callosum

Artificial intelligence scaled on a simple bet: identical chips, identical architectures, brute force. That assumption is now breaking - the problems worth solving are inherently heterogeneous, and so is the intelligence we need to solve them.

Callosum is the Intelligent Systems Company. We operate at the level of systems, not models - unifying heterogeneous compute so intelligence is matched to the problem, not defined by any single model or chip.

Tailored Inference is how we deliver this: intelligence optimised to the task, built with the world's leading silicon and infrastructure partners. It's already in production across fields like cybersecurity and finance, delivering step-change, not incremental, gains in capability and cost.

CEO
Danyal Akarca
Sector
Infrastructure
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